B群和D群沙门氏菌中体细胞抗原2的遗传
Somatic antigen 2 inheritance in Salmonella groups B and D.
作者信息
Johnson E M
出版信息
J Bacteriol. 1967 Dec;94(6):2018-21. doi: 10.1128/jb.94.6.2018-2021.1967.
Somatic (O) antigen 2 of Salmonella paratyphi A replaced somatic antigen 4 of an S. typhimurium recipient as the consequence of mating with an S. paratyphi A var. durazzo Hfr strain. The genetic determinants of these O antigens behaved in this cross as alleles of a common O locus, which is linked to the determinant of histidine biosynthesis, his. By employing phage lysates obtained by growth of P22 on an S. typhimurium hybrid which had received his and O-factor 2 determinants from the S. paratyphi A Hfr, it was possible to cotransduce the his and O-antigen 2 genes to both S. typhimurium and S. typhosa. S. typhimurium transductants which received somatic antigen 2 concurrently lost O-antigen 4, and S. typhosa transductants receiving O-antigen 2, lost their native O-antigen 9. These results indicate that the genetic determinants of O-antigens 2, 4, and 9 occupy the same O locus in S. paratyphi A, S. typhimurium, and S. typhosa, respectively, and are probably allelic.
甲型副伤寒沙门氏菌的体细胞（O）抗原2取代了鼠伤寒沙门氏菌受体的体细胞抗原4，这是与甲型副伤寒沙门氏菌杜拉佐变种高频重组（Hfr）菌株交配的结果。这些O抗原的遗传决定因素在这次杂交中表现为一个共同O位点的等位基因，该位点与组氨酸生物合成的决定因素his相连。通过使用P22在一株从甲型副伤寒沙门氏菌Hfr获得了his和O因子2决定因素的鼠伤寒沙门氏菌杂种上生长而获得的噬菌体裂解物，有可能将his和O抗原2基因共转导到鼠伤寒沙门氏菌和伤寒沙门氏菌中。同时获得体细胞抗原2的鼠伤寒沙门氏菌转导子失去了O抗原4，而获得O抗原2的伤寒沙门氏菌转导子失去了其天然的O抗原9。这些结果表明，O抗原2、4和9的遗传决定因素分别在甲型副伤寒沙门氏菌、鼠伤寒沙门氏菌和伤寒沙门氏菌中占据相同的O位点，并且可能是等位基因。
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