Johnson E M, Krauskopf B, Baron L S
J Bacteriol. 1966 Nov;92(5):1457-63. doi: 10.1128/jb.92.5.1457-1463.1966.
Johnson, E. M. (Walter Reed Army Institute of Research, Washington, D.C.), Barbara Krauskopf, and L. S. Baron. Genetic analysis of the ViA-his chromosomal region in Salmonella. J. Bacteriol. 92:1457-1463. 1966.-The relative chromosomal location of the ViA determinant, a gene required for Vi antigen expression in Salmonella typhosa (and present also in S. typhimurium), was examined in S. typhimurium x S. typhosa matings. The position of this gene was determined with respect to the histidine (his) and methionine (metG) biosynthesis markers, and to the genetic determinants of somatic antigens 5 (O-5) and 4 (O-4) of S. typhimurium. The gene order established by analyses of the hybrid classes resulting from the genetic crosses was ViA-O-5-metG-O-4 (his). This order suggests that neither ViA nor O-5 is a member of the complex of functionally related structural genes which constitute the O-4 locus. It allows for the possibility, however, of a functional relationship between the genes of the ViA and O-5 loci.
约翰逊，E.M.（华盛顿特区沃尔特·里德陆军研究所）、芭芭拉·克劳斯科普夫和L.S.巴伦。鼠伤寒沙门氏菌ViA-组氨酸染色体区域的遗传分析。《细菌学杂志》92:1457 - 1463。1966年。——在鼠伤寒沙门氏菌与伤寒沙门氏菌的杂交中，研究了ViA决定簇（伤寒沙门氏菌中Vi抗原表达所需的一个基因，鼠伤寒沙门氏菌中也存在）在染色体上的相对位置。确定了该基因相对于组氨酸（his）和甲硫氨酸（metG）生物合成标记，以及鼠伤寒沙门氏菌体细胞抗原5（O-5）和4（O-4）的遗传决定簇的位置。通过对遗传杂交产生的杂交类别进行分析所确定的基因顺序为ViA-O-5-metG-O-4（his）。这个顺序表明ViA和O-5都不是构成O-4位点的功能相关结构基因复合体的成员。然而，这使得ViA和O-5位点的基因之间存在功能关系成为可能。
