Sokol A, Gral T, Rubini M E
Calif Med. 1967 Sep;107(3):236-46.
Chronic intermittent hemodialysis may relieve some medical problems of terminal uremia (for example, azotemia, acidosis, hypertension, neuro-muscular disorders, bleeding, pericarditis) to such a degree that many patients are able to resume their normal activity. There remain, however, problems which are not readily changed by hemodialysis (anemia, peripheral neuropathy, pruritus, sexual impotence, renal osteodystrophy). These, together with medical problems possibly caused by hemodialysis (for example, osmotic disequilibrium, errors in dialysate composition, hepatitis, hemosiderosis, isoimmunization from blood transfusions, shunt problems and psychological problems of dependency upon the artificial kidney) represent a limitation of the present type of hemodialysis therapy.
慢性间歇性血液透析可在一定程度上缓解终末期尿毒症的一些医学问题（例如氮质血症、酸中毒、高血压、神经肌肉疾病、出血、心包炎），从而使许多患者能够恢复正常活动。然而，仍存在一些问题，血液透析难以轻易改变这些问题（贫血、周围神经病变、瘙痒、性功能障碍、肾性骨营养不良）。这些问题，连同可能由血液透析引起的医学问题（例如渗透失衡、透析液成分错误、肝炎、含铁血黄素沉着症、输血引起的同种免疫、分流问题以及依赖人工肾的心理问题），代表了当前这种血液透析治疗方式的局限性。
