McLeod L E, Mandin H, Davidman M, Ulan R, Lakey W H
Can Med Assoc J. 1966 Feb 12;94(7):318-27.
Seven patients with chronic renal failure underwent intermittent hemodialysis for five to 37 months (111 patient-months on a twice-weekly basis) employing arteriovenous Teflon-Silastic cannulas and the modified two-layer Kiil hemodialyzer. A single-pass 37 degrees C. dialysate system has been used. One patient died of an indirectly related cause. All other patients have been successfully rehabilitated and now carry on normal activity of moderate sedentary type. Complications included recurring infection and clotting of arteriovenous cannulas. Hypertension and anemia were common complications requiring careful control. Peripheral neuropathy was noted in five of the seven patients but was of clinical significance in only one patient. Metastatic calcification, osteoporosis and urolithiasis also occurred in this patient. Peptic ulcers with hemorrhage developed in two patients. The degree of rehabilitation and psychological adjustment achieved by this group of patients strongly indicates the need for expansion of dialysis facilities and further research into the medical and economic aspects of dialysis.
7例慢性肾功能衰竭患者采用动静脉聚四氟乙烯-硅橡胶插管和改良的双层基尔血液透析器，进行了5至37个月的间歇性血液透析（每周两次，共111个患者月）。采用了单程37摄氏度的透析液系统。1例患者死于间接相关原因。所有其他患者均已成功康复，目前从事中度久坐类型的正常活动。并发症包括动静脉插管反复感染和凝血。高血压和贫血是需要仔细控制的常见并发症。7例患者中有5例出现周围神经病变，但仅1例具有临床意义。该患者还发生了转移性钙化、骨质疏松和尿路结石。2例患者出现了伴有出血的消化性溃疡。这组患者所达到的康复程度和心理调适强烈表明需要扩大透析设施，并进一步研究透析的医学和经济方面。
