Brockington I F, Kendell R E, Wainwright S, Hillier V F, Walker J
Br J Psychiatry. 1979 Sep;135:243-8. doi: 10.1192/bjp.135.3.243.
In an attempt to demonstrate a valid boundary between schizophrenia and the affective psychoses, discriminant function analyses have been carried out with history, mental state and follow-up data in two populations of patients. A bimodal distribution of discriminant scores was obtained in one of them (a general psychotic sample of 128 patients), using a discriminant function derived from the same sample; but when the function was applied to the second population (a schizoaffective sample of 106 patients) the distribution was ambiguous. Functions derived from the schizoaffective sample produced highly skewed distributions of discriminant scores in the general psychotic sample. Kraepelin's hypothesis that the functional psychoses consist of two distinct disease entities receives some support from our findings, but there is still no compelling evidence that the universe of psychotic patients falls naturally into these two groups.
为了证明精神分裂症与情感性精神病之间存在有效的界限，对两组患者的病史、精神状态和随访数据进行了判别函数分析。在其中一组（128名患者的一般精神病样本）中，使用来自同一样本的判别函数获得了判别分数的双峰分布；但当将该函数应用于第二组人群（106名分裂情感性障碍患者样本）时，分布情况不明确。从分裂情感性障碍样本得出的函数在一般精神病样本中产生了判别分数的高度偏态分布。克雷佩林关于功能性精神病由两种不同疾病实体组成的假设从我们的研究结果中得到了一些支持，但仍然没有令人信服的证据表明精神病患者群体自然地分为这两组。
