Kuwahara S, Goto S, Kimura M, Abe H
Bull World Health Organ. 1967;37(5):763-71.
About 1500 strains of El Tor vibrios, isolated in 1964 and 1965 in the Philippines, were examined for their susceptibilities to 17 drugs. All the strains tested were highly sensitive to dihydroxymethyl-furalazine, and most were highly sensitive to tetracycline hydrochloride, chloramphenicol and erythromycin, and moderately sensitive to novobiocin, dihydrostreptomycin sulfate, kanamycin and neomycin. They showed a remarkable fluctuation of sensitivity to ampicillin, cefaloridine, cefalotin and sulfafurazole, and a high resistance to benzylpenicillin sodium, oleandomycin and spiramycin.Experimental confirmation was provided of the fact that El Tor vibrios and non-agglutinable vibrios can be distinguished from classical cholera vibrios by their resistance to polymyxin B and colistin.Highly streptomycin-resistant strains, and to a lesser extent ampicillin- and sulfafurazole-resistant strains, were relatively often isolated from cholera patients who had been treated with antibiotics. One patient yielded a strain resistant to tetracycline, chloramphenicol, streptomycin and sulfafurazole.
对1964年和1965年在菲律宾分离出的约1500株埃尔托弧菌进行了17种药物敏感性检测。所有受试菌株对二羟甲基糠醛嗪高度敏感，大多数对盐酸四环素、氯霉素和红霉素高度敏感，对新生霉素、硫酸双氢链霉素、卡那霉素和新霉素中度敏感。它们对氨苄西林、头孢噻啶、头孢噻吩和磺胺异恶唑的敏感性波动显著，对苄青霉素钠、竹桃霉素和螺旋霉素高度耐药。实验证实，埃尔托弧菌和不凝集弧菌可通过对多粘菌素B和黏菌素的耐药性与经典霍乱弧菌相区分。高度耐链霉素的菌株，以及在较小程度上耐氨苄西林和磺胺异恶唑的菌株，相对经常从接受过抗生素治疗的霍乱患者中分离出来。有一名患者分离出一株对四环素、氯霉素、链霉素和磺胺异恶唑均耐药的菌株。
