Kobari K, Uylangco C, Vasco J, Takahira Y, Shimizu N
Bull World Health Organ. 1967;37(5):751-62.
In order to determine the effect of antibiotics on the course of cholera, precise observations of clinical symptoms and quantitative examination of vibrios in the stool were carried out on 17 patients with cholera El Tor from the Philippines. Seven patients were treated orally with kanamycin, tetracycline, chloramphenicol or erythromycin, 7 intravenously with chloramphenicol or tetracycline, and 3 were not given any antibiotic.Both the oral and the intravenous routes of administration of the antibiotics were suitable for shortening the period of diarrhoea and reducing the excretion of vibrios in the stool.The number of vibrios in 1 ml of watery stool during the first day of illness was about 10(8) in every case. There was marked reduction in the number within 1 hour, and complete disappearance of vibrios within 10 hours, of the start of treatment in most cases. However, vibrios reappeared later in some cases.Kanamycin, a non-absorbable antibiotic, was found to be less effective than adsorbable antibiotics such as chloramphenicol and tetracycline.
为了确定抗生素对霍乱病程的影响，对17例来自菲律宾的埃尔托型霍乱患者的临床症状进行了精确观察，并对其粪便中的弧菌进行了定量检测。7例患者口服卡那霉素、四环素、氯霉素或红霉素，7例静脉注射氯霉素或四环素，3例未使用任何抗生素。口服和静脉注射抗生素均有助于缩短腹泻期并减少粪便中弧菌的排泄。在患病第一天，每例患者每毫升水样粪便中的弧菌数量约为10⁸ 。在大多数情况下，治疗开始后1小时内弧菌数量显著减少，10小时内弧菌完全消失。然而，在某些情况下，弧菌后来又重新出现。发现不可吸收的抗生素卡那霉素的效果不如可吸收的抗生素如氯霉素和四环素。
