Homma S
Brain Res. 1979 Sep 14;173(2):287-93. doi: 10.1016/0006-8993(79)90628-0.
(1) Input conductances of giant interneurons in the isolated spinal cord of lampreys were measured with two separate intracellular electrodes. Bath applications of 0.4--3 mM beta-alanine and taurine produced large, reversible conductance increases which were Cl-dependent. (2) Strychnine at 1--2.5 microM might be a competitive antagonist of both amino acids, but had a stronger effect on taurine. Bicuculline and picrotoxin were weak antagonists of beta-alanine and taurine in some cells. (3) A few giant interneurons desensitized after repeated application of the amino acids, but most became more sensitive. Responses to the amino acids also increase at low temperatures in in Na-free fluid, suggesting effect of uptake mechanisms.
（1）用两个独立的细胞内电极测量七鳃鳗离体脊髓中巨型中间神经元的输入电导。浴槽中加入0.4 - 3 mM的β-丙氨酸和牛磺酸可使电导大幅且可逆地增加，这种增加依赖于氯离子。（2）1 - 2.5微摩尔的士的宁可能是这两种氨基酸的竞争性拮抗剂，但对牛磺酸的作用更强。荷包牡丹碱和印防己毒素在某些细胞中是β-丙氨酸和牛磺酸的弱拮抗剂。（3）少数巨型中间神经元在反复应用氨基酸后会脱敏，但大多数会变得更加敏感。在无钠溶液中低温时对氨基酸的反应也会增加，提示存在摄取机制的作用。
