Barnhart J L, Upson D W
Can J Physiol Pharmacol. 1979 Jul;57(7):710-6. doi: 10.1139/y79-107.
Changes in the composition of bile accompanying the maximum biliary excretion (Emax) of bilirubin were investigated in sheep. Sheep fitted with chronic 'T-tubes' in the common bile duct were infused with taurocholate and bilirubin at various rates. Bile collected during both pre- and post-bilirubin steady-state periods was analyzed for the biliary concentration of electrolytes, bile salts, and bilirubin. Bilirubin Emax was 24.6 mumol/min while bile salt excretion during this period was 103 mumol/min. At Emax bilirubin entry into bile reached a concentration of 16.1 mumol/mL, increased the biliary concentration of sodium, did not change osmolarity of bile, and did not increase bile flow. The data suggest that bilirubin either interacts with mixed micelles in bile or forms molecular aggregates.
在绵羊身上研究了伴随胆红素最大胆汁排泄量（Emax）时胆汁成分的变化。给在胆总管中装有慢性“T型管”的绵羊以不同速率输注牛磺胆酸盐和胆红素。分析在胆红素稳态期前后收集的胆汁中电解质、胆盐和胆红素的胆汁浓度。胆红素Emax为24.6 μmol/分钟，而在此期间胆盐排泄量为103 μmol/分钟。在Emax时，胆红素进入胆汁的浓度达到16.1 μmol/mL，增加了胆汁中钠的浓度，未改变胆汁的渗透压，也未增加胆汁流量。数据表明，胆红素要么与胆汁中的混合微胶粒相互作用，要么形成分子聚集体。
