Regional distribution of amino acids in Friedreich's ataxia brains.
作者信息
Huxtable R, Azari J, Reisine T, Johnson P, Yamamura H, Barbeau A
出版信息
Can J Neurol Sci. 1979 May;6(2):255-8. doi: 10.1017/s0317167100119742.
PMID:487319
Abstract
The distribution of amino acids in two Friedreich's ataxia brains is compared to 4 control brains. Glutamate and GABA were decreased in the cerebellar hemispheres and/or in the vermis. Taurine concentrations were uniformly elevated throughout the areas studied. Taurine/glutamate and taurine/GABA ratios were consistently elevated in Friedreich's ataxia brains, whereas glutamate/glutamine ratios were consistently decreased (with normal glutamine concentrations).
摘要
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