注射途径对针对多种抗原产生循环抗体的影响。
The effect of route of injection upon the development of circulating antibody in response to a variety of antigens.
作者信息
Schelling M E, Silverman P H
出版信息
Immunology. 1968 Jun;14(6):781-5.
Ovalbumin, lipopolysaccharide, and a combination of metabolic and somatic antigens of were injected into rabbits via the intravenous, intramuscular, intradermal and intraperitoneal routes. Haemagglutination titres were obtained on untreated sera and sera after reduction and alkylation. The data suggest that the route of injection most efficient in stimulating the production of circulating antibody would depend upon whether the antigen in question elicits 19S globulin, 7S globulin or a combination of the two either in the form of sequential synthesis or a prolonged response of both types of immunoglobulins.
将卵清蛋白、脂多糖以及代谢和体细胞抗原的组合通过静脉内、肌肉内、皮内和腹膜内途径注射到兔子体内。对未经处理的血清以及还原和烷基化后的血清进行血凝滴度检测。数据表明，在刺激循环抗体产生方面最有效的注射途径将取决于所讨论的抗原是以19S球蛋白、7S球蛋白的形式引发，还是以两种球蛋白的顺序合成或两种类型免疫球蛋白的延长反应的形式引发两者的组合。
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