Hatle L, Angelsen B, Tromsdal A
Circulation. 1979 Nov;60(5):1096-104. doi: 10.1161/01.cir.60.5.1096.
The mean pressure drop across the mitral valve and atrioventricular pressure half-time were measured noninvasively by Doppler ultrasound in 40 normal subjects, in 17 patients with mitral regurgitation, 32 patients with mitral stenosis and 12 with combined stenosis and regurgitation. In normal subjects pressure half-times were 20--60 msec, in patients with isolated mitral regurgitation 35--80 msec and in patients with mitral stenosis 90--383 msec. There was no significant change in pressure half-time with exercise or on repeat examinations, indicating relative independence of mitral flow. In 25 patients with mitral stenosis and seven with combined stenosis and regurgitation, pressure half-time was related to mitral valve area calculated from catheterization data. Increasing pressure half-times occurred with decreasing mitral valve area, and this relationship was not influenced by additional mitral regurgitation. Noninvasive measurement of pressure half-time together with mean pressure drop was useful for evaluating patients with mitral valve disease.
通过多普勒超声对40名正常受试者、17名二尖瓣反流患者、32名二尖瓣狭窄患者以及12名合并狭窄和反流的患者进行无创测量，获取二尖瓣跨瓣平均压差和房室压力减半时间。正常受试者的压力减半时间为20 - 60毫秒，单纯二尖瓣反流患者为35 - 80毫秒，二尖瓣狭窄患者为90 - 383毫秒。运动或重复检查时压力减半时间无显著变化，提示二尖瓣血流相对独立。在25名二尖瓣狭窄患者和7名合并狭窄及反流的患者中，压力减半时间与根据心导管检查数据计算出的二尖瓣瓣口面积相关。二尖瓣瓣口面积减小，压力减半时间增加，且这种关系不受额外二尖瓣反流的影响。无创测量压力减半时间及平均压差有助于评估二尖瓣疾病患者。
