手术引起的网状内皮系统抑制的逆转
The reversal of surgically induced reticuloendothelial depression.
作者信息
Everson N W, Stacey R L, Wood R F, Bell P R
出版信息
Clin Exp Immunol. 1979 Jul;37(1):169-73.
The function of the reticuloendothelial (RE) system may be depressed by surgical operation. As this system is an important defence mechanism against tumour growth and metastasis, it would be an advantage if this depression could be prevented by the administration of a suitable agent. The agents studied in this case were levamisole, Corynebacterium parvum (C. parvum) and glucan. As a measure of RE function a carbon clearance test was performed in rats, 1 hr after partial colectomy, animals having received pre-operative treatment with one of these substances. The results show that operation produced a significant fall in clearance (P less than 0.001). Both C. parvum and glucan were very effective in preventing any fall of clearance following operation (P less than 0.01). Both of these produced marked RE stimulation and values in animals given these agents remained above control values even after surgery. Levamisole had some effect in preventing the RE depression (P less than 0.02), but was not as effective as either C. parvum or glucan.
手术操作可能会抑制网状内皮（RE）系统的功能。由于该系统是抵御肿瘤生长和转移的重要防御机制，若能通过给予合适的药物来预防这种抑制，将会是一件有益的事。本研究中所使用的药物为左旋咪唑、短小棒状杆菌（C. parvum）和葡聚糖。作为衡量RE功能的指标，在大鼠接受部分结肠切除术后1小时，对术前接受过上述其中一种物质治疗的动物进行碳清除试验。结果显示，手术导致清除率显著下降（P<0.001）。短小棒状杆菌和葡聚糖在预防术后清除率下降方面都非常有效（P<0.01）。这两种药物都能显著刺激RE，给予这些药物的动物即使在术后其数值仍高于对照值。左旋咪唑在预防RE抑制方面有一定作用（P<0.02），但不如短小棒状杆菌或葡聚糖有效。
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