腹腔注射6-羟基多巴胺对雏鸡和大鼠电休克惊厥的影响。

The influence of intraperitoneally injected 6-hydroxydopamine on electroshock seizure in chicks and rats.

Osuide G, Wambebe C

Clin Exp Pharmacol Physiol. 1979 Jul-Aug;6(4):367-72. doi: 10.1111/j.1440-1681.1979.tb00023.x.

Abstract

6-Hydroxydopamine, injected intraperitoneally in rats and chicks, did not induce spontaneous seizures but produced significant alterations in the threshold to electroshock seizure in chicks; the particular effects were dose-dependent and time-dependent. 2. Administration of 6-hydroxydopamine to 3 day old chicks and rats in the first and third days after birth resulted in an increase in the proportion exhibiting tonic seizure with electroshock when tested after 10-12 weeks. 3. When 6-hydroxydopamine was injected intraperitoneally into adult rats and cocks, there was no significant alteration in seizure threshold. 4. The results suggest that 6-hydroxydopamine penetrates the central nervous system of young chicks and rats and that adrenergic mechanisms are probably involved in modulating seizure mechanisms in both the chick and rat.

摘要

给大鼠和雏鸡腹腔注射6-羟基多巴胺不会诱发自发性癫痫发作，但会使雏鸡对电休克癫痫发作的阈值产生显著改变；这些特殊效应具有剂量依赖性和时间依赖性。2. 在出生后的第一天和第三天给3日龄的雏鸡和大鼠施用6-羟基多巴胺，在10-12周后进行测试时，出现强直性电休克癫痫发作的比例增加。3. 当给成年大鼠和公鸡腹腔注射6-羟基多巴胺时，癫痫发作阈值没有显著改变。4. 结果表明，6-羟基多巴胺可穿透幼雏鸡和大鼠的中枢神经系统，并且肾上腺素能机制可能参与调节雏鸡和大鼠的癫痫发作机制。