Belleville J P, Dorey F, BEllville J W
Clin Pharmacol Ther. 1979 Oct;26(4):457-63. doi: 10.1002/cpt1979264457.
The effects of 2 doses of nefopam, d-amphetamine, pentazocine, and placebo were studied in healthy male sleep-deprived volunteers to determine whether the drugs improved or impaired coordination and whether they induced subjective effects. A critical tracking task was used to study hand-eye coordination. D-amphetamine, 10 mg orally, significantly improved tracking performance and made subjects feel better able to perform tasks but more anxious. It also made them feel more alert, steady, sociable, and strong. Pentazocine, 45 mg intramuscularly, caused deterioration in tracking performance and was followed by reports of depression, gloominess, dreaminess, nausea, and injection site pain. There was no significant change in tracking performance or subjective effects after both doses of nefopam and placebo.
在健康的睡眠剥夺男性志愿者中研究了2种剂量的奈福泮、右旋苯丙胺、喷他佐辛和安慰剂的效果，以确定这些药物是改善还是损害了协调性，以及它们是否会产生主观效应。使用一项关键追踪任务来研究手眼协调性。口服10毫克右旋苯丙胺可显著改善追踪表现，并使受试者感觉更有能力执行任务，但会更焦虑。它还使他们感觉更警觉、稳定、善于社交且强壮。肌肉注射45毫克喷他佐辛会导致追踪表现恶化，随后有抑郁、忧郁、梦幻、恶心和注射部位疼痛的报告。两种剂量的奈福泮和安慰剂给药后，追踪表现或主观效应均无显著变化。
