Double-blind controlled trial of a micronized preparation of flumedroxone (Demigran) in prophylaxis of migraine.
作者信息
Bradley W G, Hudgson P, Foster J B, Newell D J
出版信息
Br Med J. 1968 Aug 31;3(5617):531-3. doi: 10.1136/bmj.3.5617.531.
Abstract
A double-blind cross-over trial of a micronized preparation of flumedroxone, an oral progestogen derivative, and a placebo was undertaken to determine whether this drug had prophylactic value in migraine. No benefit was found in males, or in females with no history of menstrual exacerbation of migraine. In women whose migraine was worse around the time of menstruation flumedroxone resulted in statistically fewer headaches of less severity.With the dose used in this trial (micronized flumedroxone 10 mg. t.d.s.) side-effects were frequent, the commonest being polymenorrhagia, which occurred in half the women of reproductive age.
摘要
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本文引用的文献
1
"Anovlar" as an oral contraceptive.
Br Med J. 1962 Jul 14;2(5297):75-9. doi: 10.1136/bmj.2.5297.75.
2
METHYSERGIDE IN THE PROPHYLAXIS OF MIGRAINE.
Lancet. 1964 Mar 7;1(7332):523-4. doi: 10.1016/s0140-6736(64)92910-1.
3
Methysergide and coronary artery disease.
Am Heart J. 1967 Dec;74(6):854-5. doi: 10.1016/0002-8703(67)90105-6.
4
Methysergide and retroperitoneal fibrosis.
Am Heart J. 1966 Dec;72(6):843-4. doi: 10.1016/0002-8703(66)90172-4.
5
Vascular headaches and oral contraceptives.
Ann Intern Med. 1966 Oct;65(4):863. doi: 10.7326/0003-4819-65-4-863_1.
6
Methysergide in prophylaxis of migraine: a clinical trial in general practice.
Br Med J. 1966 Aug 13;2(5510):394-5. doi: 10.1136/bmj.2.5510.394.
7
The effect of oral contraceptives on migraine.
Lancet. 1966 Apr 16;1(7442):856-9. doi: 10.1016/s0140-6736(66)90189-9.
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