Lawler S D, Pentycross C R, Reeves B R
Br Med J. 1968 Oct 26;4(5625):213-9. doi: 10.1136/bmj.4.5625.213.
In chronic lymphocytic leukaemia the majority of circulating lymphocytes which responded to phytohaemagglutinin in vitro were found to have normal karyotypes. A minor population of cells in patients treated with chemotherapy had an increased number of chromosomal rearrangements as compared with cells from normal controls and untreated patients with chronic lymphocytic leukaemia. Probably bonemarrow and lymph-node cells also had a normal karyotype.In the other lymphoproliferative disorders the peripheral blood lymphocytes had either normal karyotypes or chromosomal abnormalities attributable to treatment, even in those cases where the tumour cells of involved lymph nodes were known to have abnormal karyotypes.It was possible that circulating tumour cells were present in one case.
在慢性淋巴细胞白血病中，发现体外对植物血凝素产生反应的大多数循环淋巴细胞具有正常的核型。与正常对照以及未经治疗的慢性淋巴细胞白血病患者的细胞相比，接受化疗的患者中有一小部分细胞的染色体重排数量增加。骨髓和淋巴结细胞可能也具有正常的核型。在其他淋巴增生性疾病中，即使在已知受累淋巴结的肿瘤细胞具有异常核型的情况下，外周血淋巴细胞要么具有正常核型，要么具有因治疗导致的染色体异常。在一个病例中有可能存在循环肿瘤细胞。
