Rieben F W, Waldherr R, Oster P, Schettler G
Dtsch Med Wochenschr. 1979 Oct 12;104(41):1447-9. doi: 10.1055/s-0028-1129119.
In a 65-year-old man livedo reticularis occurred in the lower half of the body two days after beginning lysis with streptokinase. This was followed by skin and toe necrosis as well as acute renal failure. Autopsy showed a severe ulcerative atherosclerosis of the aorta with cholesterol crystal embolisation in numerous organs, particularly in both kidneys. The coincidence in time leads one to assume that the streptokinase treatment encouraged acute diffuse embolisation by dissolving the protective thrombi over the ulcerative atheromatous plaques.
一名65岁男性在开始使用链激酶溶栓治疗两天后，身体下半部出现网状青斑。随后出现皮肤和脚趾坏死以及急性肾衰竭。尸检显示主动脉严重溃疡性动脉粥样硬化，多个器官尤其是双肾有胆固醇结晶栓塞。时间上的巧合使人认为链激酶治疗通过溶解溃疡性动脉粥样硬化斑块上的保护性血栓，促使了急性弥漫性栓塞的发生。
