放射性铬在垂体切除和肾上腺切除大鼠体内的分布。

Radiochromium distribution in hypophysectomized and adrenalectomized rats.

作者信息

Jain R, Wallach S, Peabody R A, Verch R L, Agrawal R, Taylor R

出版信息

Endocrinology. 1979 Nov;105(5):1226-9. doi: 10.1210/endo-105-5-1226.

Abstract

The effects of hypophyseal and adrenal ablation (HYPOX, ADX) on trivalent radiochromium (51Cr) distribution and of GH and T4 replacement in HYPOX rats were determined. Hypophysectomy increased body retention of 51Cr by 20--35%, and hormonal replacement restored body retention to normal. Serum 51Cr was increased 300--800%, resulting in depressed tissue to serum 51Cr ratios. GH replacement partially restored the 51Cr distribution abnormalities in HYPOX rats to normal. The combination of T4 with GH enhanced the restoration of normal 51Cr distribution, and tissue to serum 51Cr ratios returned to baseline levels. ADX had no effect on body retention of 51Cr but had a small effect on increases in serum and tissue 51Cr levels. As a result, tissue to serum 51Cr ratios did not change. These data indicate that in the HYPOX state there is a marked disturbance in Cr metabolism which is due to deficiencies of both GH and T4. Whether or not adrenal hormones are envolved in 51Cr distribution will require further study.

摘要

测定了垂体切除和肾上腺切除（垂体切除、肾上腺切除）对三价放射性铬（⁵¹Cr）分布的影响，以及生长激素（GH）和甲状腺素（T4）对垂体切除大鼠的替代作用。垂体切除使⁵¹Cr的体内潴留增加20% - 35%，激素替代使体内潴留恢复正常。血清⁵¹Cr升高300% - 800%，导致组织与血清⁵¹Cr比值降低。生长激素替代部分恢复了垂体切除大鼠⁵¹Cr分布异常至正常。甲状腺素与生长激素联合使用增强了⁵¹Cr正常分布的恢复，组织与血清⁵¹Cr比值恢复到基线水平。肾上腺切除对⁵¹Cr的体内潴留无影响，但对血清和组织⁵¹Cr水平的升高有轻微影响。结果，组织与血清⁵¹Cr比值没有变化。这些数据表明，在垂体切除状态下，由于生长激素和甲状腺素的缺乏，铬代谢存在明显紊乱。肾上腺激素是否参与⁵¹Cr分布还需要进一步研究。