Lifschitz M L, Wallach S, Peabody R A, Verch R L, Agrawal R
Am J Clin Nutr. 1980 Jan;33(1):57-62. doi: 10.1093/ajcn/33.1.57.
Body retention and tissue distribution of a 51chromium (Cr) tracer were studied in thyroparathyroidectomized (TPTX) rats and in TPTX rats after replacement with thyroxin, calcitonin, or parathyroid hormone. A tracer dose containing 1 ng Cr or less and 0.5 to 0.7 muCi of high specific activity 51Cr (Cr III) was injected intravenously in control, TPTX, and TPTX animals receiving hormone replacement. Three days later, the 51Cr content of the serum and various tissues was determined and the data were expressed as percent dose per milliliter or gram and as tissue: serum 51Cr ratios. TPTX resulted in a significant increase in total body 51Cr retention and 40 to 240% increases in serum and tissue 51Cr levels. Tissue:serum 51Cr ratios were uniformly depressed. Replacement with thyroxin completely or partially reversed these changes in all tissues studied except bone. Calcitonin and parathyroid hormone had no consistent effect on body, serum, or tissue 51Cr levels. These data, indicating that 51Cr distribution is influenced by thyroid hormone activity but not by calcitonin or parathyroid hormone, are compatible with the hypothesis that thyroid hormone controls cellular Cr transport.
在甲状腺甲状旁腺切除（TPTX）大鼠以及用甲状腺素、降钙素或甲状旁腺激素替代的TPTX大鼠中，研究了51铬（Cr）示踪剂的体内潴留和组织分布。向对照、TPTX以及接受激素替代的TPTX动物静脉注射含1 ng或更少Cr以及0.5至0.7 μCi高比活度51Cr（Cr III）的示踪剂量。三天后，测定血清和各种组织的51Cr含量，数据表示为每毫升或每克的剂量百分比以及组织：血清51Cr比值。TPTX导致全身51Cr潴留显著增加，血清和组织51Cr水平增加40%至240%。组织：血清51Cr比值均降低。除骨骼外，用甲状腺素替代可完全或部分逆转所有研究组织中的这些变化。降钙素和甲状旁腺激素对全身、血清或组织51Cr水平没有一致的影响。这些数据表明51Cr分布受甲状腺激素活性影响，但不受降钙素或甲状旁腺激素影响，这与甲状腺激素控制细胞Cr转运的假说相符。
