两个德国家庭中血浆酶活性高的一种罕见的、由基因决定的假性胆碱酯酶变体。

A rare genetically determined variant of psuedocholinesterase in two German families with high plasma enzyme activity.

作者信息

Delbrück A, Henkel E

出版信息

Eur J Biochem. 1979 Aug 15;99(1):65-9. doi: 10.1111/j.1432-1033.1979.tb13231.x.

DOI:10.1111/j.1432-1033.1979.tb13231.x

Abstract

Activity of pseudocholinesterase (acylcholine-acyl-hydrolase) elevated up to four times has been detected in sera of members of two German families. The catalytic concentrations of the pseudocholinesterase of the afflicted members of both families (male and female) varied between 4800 U/l and 10 200 U/o (acetylthiocholine iodide substrate). The pseudocholinesterase of the propositi exhibits isoenzyme separation patterns in polyacrylamide electrophoresis as well as in electrofocussing which are different from those of pseudocholinesterase from normal persons. No differences could be seen as regards the Km of substrates or the inhibition by dibucaine, fluoride or succinyldiocholine.

摘要

在两个德国家庭成员的血清中，已检测到假胆碱酯酶（酰基胆碱 - 酰基水解酶）活性升高至四倍。两个家庭中患病成员（男性和女性）的假胆碱酯酶催化浓度在4800 U/l至10200 U/o（碘化硫代乙酰胆碱底物）之间变化。先证者的假胆碱酯酶在聚丙烯酰胺电泳和电聚焦中显示出同工酶分离模式，与正常人的假胆碱酯酶不同。在底物的Km或丁卡因、氟化物或琥珀酰二胆碱的抑制方面未见差异。