转铁蛋白、假性胆碱酯酶与1号染色体位点的遗传连锁研究。

Genetic linkage studies of transferrin, pseudocholinesterase, and chromosome 1 loci.

作者信息

Sparkes R S, Field L L, Sparkes M C, Crist M, Spence M A, James K, Garry P J

出版信息

Hum Hered. 1984;34(2):96-100. doi: 10.1159/000153442.

Abstract

Genetic linkage analysis of a pedigree with four different alleles for pseudocholinesterase (CHE1) gives a positive lod score of 0.37 at theta = 0.16 for linkage with transferrin (TF), a finding which supports previous reports of linkage between CHE1 and TF. Evaluation of linkage relations of CHE1 and TF using unreported families from our data bank fails to establish linkage with chromosome 1 loci (6-PGD, Rh, PGM1, AMY2 and FY). These results are consistent with recent studies which suggest that TF is on human chromosome 3.

摘要

对一个具有四种不同假胆碱酯酶（CHE1）等位基因的家系进行遗传连锁分析，在θ = 0.16时，与转铁蛋白（TF）连锁的lod得分为0.37，这一结果支持了之前关于CHE1和TF之间连锁的报道。利用我们数据库中未报告的家系评估CHE1和TF的连锁关系，未能确定与1号染色体位点（6 - 磷酸葡萄糖脱氢酶、Rh、磷酸葡萄糖变位酶1、淀粉酶2和Fy）的连锁。这些结果与最近表明TF位于人类3号染色体上的研究一致。