中枢毒蕈碱受体的突触前和突触后定位。
Pre- and postsynaptic localization of central muscarinic receptors.
作者信息
Aguilar J S, Criado M, De Robertis E
出版信息
Eur J Pharmacol. 1979 Aug 1;57(2-3):227-30. doi: 10.1016/0014-2999(79)90369-8.
PMID:488161
Abstract
3H-Quinuclidinyl benzylate and dimethyl 14C-d-tubocurarine were used to localize muscarinic and nicotinic receptors in synaptosomal membranes of the rat cerebral cortex. The results obtained, after the action of different concentrations of Triton X-100, suggest that, while nicotinic receptors are postsynaptic, the muscarinic ones are both pre- and postsynaptic.
摘要
3H-苄基喹宁环和二甲基14C-d-筒箭毒碱被用于定位大鼠大脑皮质突触体膜中的毒蕈碱型和烟碱型受体。在不同浓度的 Triton X-100 作用后获得的结果表明，烟碱型受体位于突触后，而毒蕈碱型受体在突触前和突触后均有分布。
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