电惊厥休克对中枢胆碱能（毒蕈碱）受体的影响。

Effect of electroconvulsive shock on central cholinergic (muscarinic) receptors.

作者信息

Gulati A, Nath C, Dhawan K N, Bhargava K P, Agarwal A K, Seth P K

出版信息

Brain Res. 1982 May 27;240(2):357-8. doi: 10.1016/0006-8993(82)90236-0.

Abstract

Sensitivity of central cholinergic (muscarinic) receptors was studied in rats after application of single and repeated (once daily for 7 days) electroconvulsive shocks (ECS). Oxotremorine-induced tremor was significantly enhanced after single as well as chronic exposure to ECS; [3H]QNB binding in frontal cortex was also significantly increased by chronic ECS. The results indicate that ECS develops supersensitivity in central muscarinic receptors.

摘要

在对大鼠施加单次和重复（每日一次，共7天）电惊厥休克（ECS）后，研究了中枢胆碱能（毒蕈碱型）受体的敏感性。单次以及长期暴露于ECS后，氧化震颤素诱发的震颤显著增强；长期ECS也使额叶皮质中[3H]QNB结合显著增加。结果表明，ECS会使中枢毒蕈碱型受体产生超敏感性。