氟哌利多对多巴胺诱导的离体犬动脉舒张作用的拮抗作用。

Antagonism by droperidol of dopamine-induced relaxation in isolated dog arteries.

作者信息

Toda N, Hatano Y

出版信息

Eur J Pharmacol. 1979 Aug 1;57(2-3):231-8. doi: 10.1016/0014-2999(79)90370-4.

Abstract

Dopamine caused a dose-related relaxation in helically cut strips of dog coronary and renal arteries treated with phenoxybenzamine andcontracted with prostaglandin F2 alpha. The dose-response curve to dopamine was shifted to the right by droperidol in concentrations above 3 X 10(-5) M. Adenosine-induced relaxations were not attenuated by droperidol. The dose--relaxation curve to isoproterenol was also shifted to the right by droperidol. Propranolol (10(-6) M) failed to significantly alter the dose response curve to dopamine, and in propranolol-treated preparations the antagonism by droperidol of dopamine actions was practically identical with that in control preparations. Droperidol appears to act as a reversible, surmountable antagonist to dopamine actions on dog arterial smooth muscles, and such evidence supports the hypothesis of specific dopamine receptors in dog arteries.

摘要

在经苯氧苄胺处理并用前列腺素F2α收缩的犬冠状动脉和肾动脉螺旋切片中，多巴胺引起剂量相关的舒张。当氟哌利多浓度高于3×10⁻⁵M时，多巴胺的剂量-反应曲线右移。腺苷诱导的舒张未被氟哌利多减弱。异丙肾上腺素的剂量-舒张曲线也被氟哌利多右移。普萘洛尔（10⁻⁶M）未能显著改变多巴胺的剂量反应曲线，在普萘洛尔处理的制剂中，氟哌利多对多巴胺作用的拮抗作用与对照制剂几乎相同。氟哌利多似乎对多巴胺作用于犬动脉平滑肌起可逆、可克服的拮抗作用，此类证据支持犬动脉中存在特异性多巴胺受体的假说。