多巴胺和去甲肾上腺素对犬离体脑动脉的影响。
Influence of dopamine and noradrenaline on isolated cerebral arteries of the dog.
作者信息
Toda N
出版信息
Br J Pharmacol. 1976 Sep;58(1):121-6. doi: 10.1111/j.1476-5381.1976.tb07700.x.
Abstract
1 Effects of dopamine and noradrenaline were compared in helically-cut strips of canine cerebral arteries. 2 Dopamine caused a greater maximal contraction than noradrenaline, although the ED50 for noradrenaline was appreciably less. The contraction induced by these amines was reversed to a relaxation by treatment with phenoxybenzamine. 3 Relaxation induced by dopamine in phenoxybenzamine-treated and prostaglandin-contracted cerebral arteries was not influenced by 1 muM propranolol, while relaxation induced by noradrenaline at low concentrations (2 muM and 10 muM) was significantly attenuated. Neither aminophylline nor atropine affected the relaxant effect of dopamine. 4 A mechanism other than beta-adrenergic, cholinergic or adenosine-related appears to be involved in the relaxation elicited by dopamine in cerebral arterial strips.
摘要
- 在犬脑动脉螺旋切片中比较了多巴胺和去甲肾上腺素的作用。2. 多巴胺引起的最大收缩幅度比去甲肾上腺素大，尽管去甲肾上腺素的半数有效剂量（ED50）明显更小。用酚苄明处理后，这些胺类诱导的收缩转变为舒张。3. 在酚苄明处理且经前列腺素收缩的脑动脉中，多巴胺诱导的舒张不受1μM普萘洛尔的影响，而去甲肾上腺素在低浓度（2μM和10μM）时诱导的舒张则显著减弱。氨茶碱和阿托品均不影响多巴胺的舒张作用。4. 多巴胺在脑动脉条中引起的舒张似乎涉及一种不同于β-肾上腺素能、胆碱能或腺苷相关的机制。
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