从NZB-NZW小鼠肾脏病变中洗脱抗核因子。
Elution of antinuclear factor from renal lesions of NZB-NZW mice.
作者信息
McGiven A R, Ironside P N
出版信息
Clin Exp Immunol. 1968 Sep;3(7):665-9.
Abstract
Immunoglobulins could be eluted from the glomerular lesions of adult NZB/NZW mice by treatment with acid citrate buffer (pH 3·4). Antinuclear activity was detected in the eluates obtained from homogenates of the kidneys of four out of six mice and from one of two glomerular preparations from two other mice. It is suggested that ANF, as a component of circulating antigen–antibody complexes trapped in the glomeruli, may play a pathogenic role in the development of the glomerular lesions of NZB/NZW mice.
摘要
用酸性枸橼酸盐缓冲液（pH 3·4）处理可从成年NZB/NZW小鼠的肾小球病变中洗脱免疫球蛋白。在6只小鼠中，有4只小鼠肾脏匀浆以及另外2只小鼠的2个肾小球标本中的1个所获得的洗脱液中检测到了抗核活性。有人提出，作为被困在肾小球中的循环抗原 - 抗体复合物的一个组成部分，抗核因子（ANF）可能在NZB/NZW小鼠肾小球病变的发展中起致病作用。
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本文引用的文献
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