McGiven A R, Hunt J S, Day W A, Jackson A E
Br J Exp Pathol. 1981 Feb;62(1):59-64.
Comparative studies of glomerular cultures from NZB/W and normal control mice aged 2, 4, 6, 8, 10 and 12 months revealed a significant increase in the number of phagocytic cells in cultures from NZB/W mice at all ages. These cells on electron microscopy had the appearance of macrophages and on immunofluorescence showed Fc receptors and reacted with rabbit anti-mouse macrophage serum. The cells appear to be of blood monocyte origin and it is likely that they play a role in the pathogenesis in NZB/W mice of the glomerulopathy associated with clearance of immune complexes.
对2、4、6、8、10和12月龄的NZB/W小鼠和正常对照小鼠的肾小球培养物进行的比较研究显示，在所有年龄段，NZB/W小鼠培养物中吞噬细胞的数量都显著增加。这些细胞在电子显微镜下呈现巨噬细胞的外观，在免疫荧光下显示Fc受体，并与兔抗小鼠巨噬细胞血清发生反应。这些细胞似乎起源于血液单核细胞，它们可能在NZB/W小鼠与免疫复合物清除相关的肾小球病发病机制中发挥作用。
