苏铁素：体内相关诱变活性的检测
Cycasin: detection of associated mutagenic activity in vivo.
作者信息
Gabridge M G, Denunzio A, Legator M S
出版信息
Science. 1969 Feb 14;163(3868):689-91. doi: 10.1126/science.163.3868.689.
PMID:4883889
Abstract
Cycasin and its lagycone, methylazoxymethanol, increase the mutant frequency of Salmonella typhimurium histidine auxotrophs when tested in the hostmediated assay. As expected, the degree of cycasin-related mutagenic activity depends on the facility with which the compound can be enzymatically deglucosylated by the normal intestinal flora.
摘要
在宿主介导试验中进行测试时，苏铁素及其糖苷配基甲基氧化偶氮甲醇会增加鼠伤寒沙门氏菌组氨酸营养缺陷型的突变频率。正如预期的那样，与苏铁素相关的诱变活性程度取决于该化合物被正常肠道菌群酶促去糖基化的难易程度。
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