Sharman D, Chantler E, Dukes M, Hutchinson F G, Elstein M
Fertil Steril. 1986 Feb;45(2):259-64. doi: 10.1016/s0015-0282(16)49165-x.
The effect on sperm motility of nonoxynol-9 chlorhexidine diacetate was compared in semen and cervical mucus. Both compounds had similar spermicidal potency in semen, abolishing sperm motility within 3 minutes at 0.5 mg/ml. When these compounds were allowed to diffuse into mucus, the subsequent survival of sperm in the mucus was different. Restricted penetration and loss of motility occurred rapidly after treatment with 0.1 mg/ml chlorhexidine, whereas sperm survived normally in mucus after prolonged contact with 200 mg/ml chlorhexidine. When the compounds were mixed directly with the mucus before sperm penetration was attempted, chlorhexidine still immobilized sperm, but concentrations of nonoxynol-9 that would be spermicidal in semen had no effect in mucus.
在精液和宫颈黏液中比较了壬苯醇醚-9和醋酸氯己定对精子活力的影响。两种化合物在精液中的杀精效力相似，在0.5毫克/毫升时3分钟内即可消除精子活力。当这些化合物扩散到黏液中时，精子在黏液中的后续存活情况有所不同。用0.1毫克/毫升醋酸氯己定处理后，精子穿透受限且活力迅速丧失，而与200毫克/毫升醋酸氯己定长时间接触后，精子在黏液中能正常存活。当在试图让精子穿透之前将化合物直接与黏液混合时，醋酸氯己定仍能使精子失去活力，但在精液中具有杀精作用的壬苯醇醚-9浓度在黏液中却没有效果。
