Meyer J C, Grundmann H P, Weiss H, Trachsel H
Dermatologica. 1979;159(5):383-5.
Delayed type hypersensitivity against staphylococcal antigens could be induced in guinea pigs by injecting the animals with a staphylococcal homogenate in Freund's adjuvant in all four foot pads and the nuchal skin. Maximal skin reactivity, tested intracutaneously, was observed 21 days after sensitization. Highest stimulation of lymph node cells and peripheral blood lymphocytes was also obtained 21 days after sensitization. When comparing cell walls, cell materials (nonsoluble material obtained after the separation of the cell wall fraction) and soluble fraction (obtained after sedimentation of all nonsoluble material, the strongest skin test reactions occurred after testing intracutaneously with the cell wall fraction.
通过在豚鼠的四个脚垫和颈部皮肤中注射弗氏佐剂中的葡萄球菌匀浆，可诱导豚鼠对葡萄球菌抗原产生迟发型超敏反应。致敏后21天，通过皮内注射检测到最大皮肤反应性。致敏后21天也获得了淋巴结细胞和外周血淋巴细胞的最高刺激。比较细胞壁、细胞物质（细胞壁部分分离后获得的不溶性物质）和可溶性部分（所有不溶性物质沉淀后获得）时，皮内注射细胞壁部分后皮肤试验反应最强。
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