双嘧达莫治疗脑血管疾病的对照试验。
Controlled trial of dipyridamole in cerebral vascular disease.
作者信息
Acheson J, Danta G, Hutchinson E C
出版信息
Br Med J. 1969 Mar 8;1(5644):614-5. doi: 10.1136/bmj.1.5644.614.
Abstract
A controlled double-blind study of the effect of dipyridamole was performed in 169 patients with established cerebral vascular disease. A dose of 400 mg. was used initially, given daily for an average of 14 months; the dose was then increased to 800 mg. daily for a further average period of 11 months. When the incidence of cerebral ischaemic episodes during treatment was compared in the drug-treated and placebo-treated groups no significant difference was found.
摘要
对169例已确诊的脑血管疾病患者进行了一项关于双嘧达莫疗效的对照双盲研究。初始剂量为400毫克，每日服用，平均服用14个月；然后剂量增加至每日800毫克，再平均服用11个月。比较药物治疗组和安慰剂治疗组在治疗期间脑缺血发作的发生率，未发现显著差异。
相似文献
1
Controlled trial of dipyridamole in cerebral vascular disease.双嘧达莫治疗脑血管疾病的对照试验。
Br Med J. 1969 Mar 8;1(5644):614-5. doi: 10.1136/bmj.1.5644.614.
2
Dose titration to reduce dipyridamole-related headache.
Cerebrovasc Dis. 2006;22(4):258-62. doi: 10.1159/000094013. Epub 2006 Jun 20.
3
Dipyridamole for preventing stroke and other vascular events in patients with vascular disease.双嘧达莫用于预防血管疾病患者的中风及其他血管事件。
Cochrane Database Syst Rev. 2003(1):CD001820. doi: 10.1002/14651858.CD001820.
4
Antiplatelet profiles of the fixed-dose combination of extended-release dipyridamole and low-dose aspirin compared with clopidogrel with or without aspirin in patients with type 2 diabetes and a history of transient ischemic attack: a randomized, single-blind, 30-day trial.缓释双嘧达莫与低剂量阿司匹林固定剂量组合与氯吡格雷联合或不联合阿司匹林在2型糖尿病和短暂性脑缺血发作病史患者中的抗血小板谱：一项随机、单盲、30天试验。
Clin Ther. 2008 Feb;30(2):249-59. doi: 10.1016/j.clinthera.2008.02.006.
5
Aspirin plus dipyridamole versus aspirin alone after cerebral ischaemia of arterial origin (ESPRIT): randomised controlled trial.动脉源性脑缺血后阿司匹林联合双嘧达莫与单用阿司匹林的疗效比较（ESPRIT）：随机对照试验
Lancet. 2006 May 20;367(9523):1665-73. doi: 10.1016/S0140-6736(06)68734-5.
6
European stroke prevention study 2: dipyridamole and acetylsalicylic acid in the secondary prevention of stroke.欧洲卒中预防研究2：双嘧达莫与阿司匹林在卒中二级预防中的应用
Int J Clin Pract. 1997 Jun;51(4):205-8.
7
A perspective on platelet-suppressant drug treatment in coronary artery and cerebrovascular disease.冠状动脉疾病和脑血管疾病中血小板抑制药物治疗的观点
Circulation. 1980 Dec;62(6 Pt 2):V111-21.
8
The European Stroke Prevention Study (ESPS): results by arterial distribution.
Ann Neurol. 1991 Jun;29(6):596-600. doi: 10.1002/ana.410290605.
9
Early treatment with aspirin plus extended-release dipyridamole for transient ischaemic attack or ischaemic stroke within 24 h of symptom onset (EARLY trial): a randomised, open-label, blinded-endpoint trial.症状发作 24 小时内使用阿司匹林加缓释双嘧达莫进行早期治疗短暂性脑缺血发作或缺血性脑卒中（EARLY 试验）：一项随机、开放标签、盲终点试验。
Lancet Neurol. 2010 Feb;9(2):159-66. doi: 10.1016/S1474-4422(09)70361-8. Epub 2010 Jan 7.
10
Effects of Dose Titration on Dipyridamole-Induced Headache: A Randomized, Double-Blind Clinical Trial.剂量滴定对双嘧达莫诱发头痛的影响：一项随机双盲临床试验
Cerebrovasc Dis. 2022;51(4):493-498. doi: 10.1159/000521083. Epub 2022 Jan 14.
引用本文的文献
1
Antiplatelet regimens after ischemic stroke or transient ischemic attack: a systematic review and updated network meta-analysis.缺血性中风或短暂性脑缺血发作后的抗血小板治疗方案：一项系统评价与更新的网状Meta分析
Ann Transl Med. 2022 Mar;10(5):245. doi: 10.21037/atm-21-3748.
2
Antithrombotic Therapy for Secondary Prevention in Patients with Non-Cardioembolic Stroke or Transient Ischemic Attack: A Systematic Review.非心源性卒中或短暂性脑缺血发作患者二级预防的抗栓治疗：一项系统评价
Life (Basel). 2021 May 15;11(5):447. doi: 10.3390/life11050447.
3
Comparative Efficacy and Safety of Nine Anti-Platelet Therapies for Patients with Ischemic Stroke or Transient Ischemic Attack: a Mixed Treatment Comparisons.九种抗血小板疗法对缺血性中风或短暂性脑缺血发作患者的疗效和安全性比较：混合治疗比较
Mol Neurobiol. 2017 Mar;54(2):1456-1466. doi: 10.1007/s12035-016-9739-z. Epub 2016 Feb 5.
4
Current areas of investigation on the medical management of stroke.当前中风医学管理的研究领域。
Calif Med. 1971 Sep;115(3):51.
5
THE PATHOGENESIS OF PULMONARY ARTERIOSCLEROSIS: PROPHYLAXIS WITH DRUGS WHICH AFFECT PLATELET AGGREGATION.肺动脉硬化的发病机制：使用影响血小板聚集的药物进行预防。
Cardiovasc Dis. 1974;1(2):137-152.
6
Clinical pharmacokinetics of antiplatelet agents used in the secondary prevention of stroke.用于卒中二级预防的抗血小板药物的临床药代动力学
Clin Pharmacokinet. 2003;42(10):909-20. doi: 10.2165/00003088-200342100-00003.
7
Rapid development of tolerance to dipyridamole-associated headaches.对双嘧达莫相关头痛的耐受性迅速发展。
Br J Clin Pharmacol. 1999 Nov;48(5):750-5. doi: 10.1046/j.1365-2125.1999.00072.x.
8
Do we still need dipyridamole?我们仍然需要双嘧达莫吗？
Br J Clin Pharmacol. 1998 Apr;45(4):323-8. doi: 10.1046/j.1365-2125.1998.t01-1-00677.x.
9
North of England evidence based guideline development project: guideline on the use of aspirin as secondary prophylaxis for vascular disease in primary care. North of England Aspirin Guideline Development Group.英格兰北部循证指南制定项目：初级保健中阿司匹林用于血管疾病二级预防的指南。英格兰北部阿司匹林指南制定小组。
BMJ. 1998 Apr 25;316(7140):1303-9. doi: 10.1136/bmj.316.7140.1303.
10
Current management of ischaemic stroke.缺血性中风的当前管理
J Neurol Neurosurg Psychiatry. 1993 Jan;56(1):6-16. doi: 10.1136/jnnp.56.1.6.
本文引用的文献
1
[The effect of Persantin on heart muscle sarcosomes].潘生丁对心肌肌粒的作用
Experientia. 1961 Sep 15;17:415-6. doi: 10.1007/BF02157978.
2
LONG TERM DIPYRIDAMOLE THERAPY OF ANGINA PECTORIS.
Am J Cardiol. 1965 Aug;16:234-7. doi: 10.1016/0002-9149(65)90478-9.
3
PERSANTIN-- A DOUBLE BLIND STUDY.潘生丁——一项双盲研究。
Angiology. 1964 Jun;15:290-2. doi: 10.1177/000331976401500608.
4
EXPERIMENTAL STUDIES ON THE EFFECTS OF PERSANTIN WITH NORMAL AND GO-DOGS.潘生丁对正常和患犬影响的实验研究
Bull Osaka Med Sch. 1963 Apr;9:106-28.
5
AUGMENTATION OF INTERCORONARY ANASTOMOSIS BY LONG-TERM ADMINISTRATION OF A VASODILATOR DRUG, DIPYRIDAMOLE (PERSANTIN).通过长期服用血管扩张剂双嘧达莫（潘生丁）增强冠状动脉间吻合术
Can Med Assoc J. 1964 Apr 18;90(16):970-3.
6
Evaluation of dipyridamole (Persantin).双嘧达莫（潘生丁）的评估。
Am Heart J. 1963 Mar;65:423-4. doi: 10.1016/0002-8703(63)90018-8.
7
8
Experimental and clinical observations on 2,6-bis-(diethanolamino)-4,8-dipiperidino-pyrimido-(5,4-d) pyrimidine (Persantin).
Am J Med Sci. 1962 Jun;243:783-9. doi: 10.1097/00000441-196206000-00009.
9
[Function and energy metabolism of the exhausted heart muscle under the effects of 2,6-bis-(diethanolamino)-4,8-dipiperidino-pyrimido-(5,4-d)-pyrimidine].
Arzneimittelforschung. 1962 Jul;12:683-91.
10
Controlled double-blind trial of "persantin" in treatment of angina pectoris.“潘生丁”治疗心绞痛的对照双盲试验。
Br Med J. 1960 Sep 17;2(5202):835. doi: 10.1136/bmj.2.5202.835.
Zotero 插件