Kobayashi M, Olefsky J M
Diabetologia. 1979 Aug;17(2):111-6. doi: 10.1007/BF01222211.
Glucose oxidation and lipogenesis were studied in isolated adipocytes from control and non-obese, experimentally hyperinsulinaemic rats. In cells from the hyperinsulinaemic animals oxidation of either [1(-14) C]- or [6(-14) C] glucose was increased in the presence or absence of insulin, at substrate concentrations from 0.1 to 20 mmol/l. Glucose incorporation into total triglycerides and fatty acids was also increased. These enhanced rates of glucose metabolism were due to increased activity of the glucose transport system in addition to increased activity of intracellular glucose metabolism. Therefore, these data indicate that insulin can influence long term glucose homoeostasis by augmenting the overall cellular capacity for glucose metabolism at several loci.
在对照大鼠以及非肥胖、实验性高胰岛素血症大鼠的分离脂肪细胞中研究了葡萄糖氧化和脂肪生成。在高胰岛素血症动物的细胞中，无论有无胰岛素，当底物浓度为0.1至20 mmol/l时，[1(-14)C]-或[6(-14)C]葡萄糖的氧化均增加。葡萄糖掺入总甘油三酯和脂肪酸的量也增加。这些葡萄糖代谢速率的提高是由于葡萄糖转运系统活性增加以及细胞内葡萄糖代谢活性增加所致。因此，这些数据表明胰岛素可通过增强细胞在多个位点的整体葡萄糖代谢能力来影响长期葡萄糖稳态。
