胰岛素对成年年龄匹配的雄性和雌性大鼠性腺脂肪组织分离脂肪细胞中葡萄糖转运和代谢的影响。
Effect of insulin on glucose transport and metabolism in isolated fat-cells of gonadal adipose tissue from mature age-matched male and female rats.
作者信息
Guerre-Millo M, Leturque A, Lavau M, Girard J
出版信息
Biochem J. 1985 Jan 15;225(2):343-8. doi: 10.1042/bj2250343.
Insulin action on glucose transport and metabolism was studied in paraovarian adipocytes from 3-month-old female rats and compared with insulin action in epididymal adipocytes from closely age-matched males. At maximal insulin concentrations the stimulations of 2-deoxyglucose uptake (4-fold the basal value) and of [U-14C]glucose incorporation into CO2 and total lipids (3- and 2-fold the basal values respectively) were similar in adipocytes from rats of both sexes. At submaximal insulin concentrations (less than 0.2 nM) the ability of paraovarian adipocytes to transport and to metabolize glucose was higher than that of epididymal adipocytes; accordingly an increase in insulin binding was observed in paraovarian adipocytes as compared with epididymal adipocytes. These results show that paraovarian adipocytes from mature female rats were highly responsive to insulin, and exhibited a higher sensitivity to the hormone than did epididymal adipocytes from male rats of the same age.
研究了胰岛素对3月龄雌性大鼠卵巢旁脂肪细胞葡萄糖转运和代谢的作用，并将其与年龄相近的雄性大鼠附睾脂肪细胞中的胰岛素作用进行比较。在最大胰岛素浓度下，两性大鼠脂肪细胞中2-脱氧葡萄糖摄取（基础值的4倍）以及[U-14C]葡萄糖掺入二氧化碳和总脂质（分别为基础值的3倍和2倍）的刺激作用相似。在低于最大胰岛素浓度（小于0.2 nM）时，卵巢旁脂肪细胞转运和代谢葡萄糖的能力高于附睾脂肪细胞；因此，与附睾脂肪细胞相比，卵巢旁脂肪细胞中观察到胰岛素结合增加。这些结果表明，成熟雌性大鼠的卵巢旁脂肪细胞对胰岛素高度敏感，并且与同年龄雄性大鼠的附睾脂肪细胞相比，对该激素表现出更高的敏感性。
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