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单个细胞明显产生两种类型的抗体。

Apparent production of 2 types of antibdoies by a single cell.

作者信息

Michael J G, Marcus R

出版信息

Science. 1968 Mar 15;159(3820):1247-9. doi: 10.1126/science.159.3820.1247.

DOI:10.1126/science.159.3820.1247
PMID:4886080
Abstract

Immunization of mice with bacterial, sheep red cells coated with antigen resulted in apparent production of antibody-forming plaques with specificities for both hemolysis and bactericidal activity. The secondary response for production of these bifunctional types of plaques could be induced by red blood cells or bacteria alone. A significant mutual suppression of immune response between the two immunizing agents was observed.

摘要

用涂有抗原的细菌、绵羊红细胞对小鼠进行免疫，导致明显产生了对溶血和杀菌活性均具有特异性的抗体形成斑。单独使用红细胞或细菌即可诱导产生这些双功能类型斑的二次应答。观察到两种免疫剂之间存在显著的免疫应答相互抑制作用。

相似文献

1
Apparent production of 2 types of antibdoies by a single cell.单个细胞明显产生两种类型的抗体。
Science. 1968 Mar 15;159(3820):1247-9. doi: 10.1126/science.159.3820.1247.
2
Cell to cell interaction in the immune response. II. The source of hemolysin-forming cells in irradiated mice given bone marrow and thymus or thoracic duct lymphocytes.免疫反应中的细胞间相互作用。II. 给受照射小鼠输注骨髓、胸腺或胸导管淋巴细胞后溶血素形成细胞的来源。
J Exp Med. 1968 Oct 1;128(4):821-37. doi: 10.1084/jem.128.4.821.
3
Effects of radiation on direct and developed spleen hemolysin plaque-forming cells of mice.
J Immunol. 1968 Nov;101(5):973-8.
4
[Effect of rubomycin B and C on formation of hemagglutinins and on the content of antibody-forming cells in the spleen of mice, following administration of sheep erythrocytes as antigen].[以绵羊红细胞为抗原给药后，柔红霉素B和C对小鼠脾脏中血凝素形成及抗体形成细胞含量的影响]
Antibiotiki. 1968 Nov;13(11):1022-6.
5
Cellular kinetics of 19S and 7S hemolysin production in mice under the influence of bacterial endotoxins.细菌内毒素影响下小鼠体内19S和7S溶血素产生的细胞动力学
Pathol Microbiol (Basel). 1970;35(5):324-37. doi: 10.1159/000162243.
6
Antibody inhibition of the immune response: experimental analysis of the site of action in vivo.
J Immunol. 1971 Jan;106(1):143-9.
7
Nucleases in immunity. II. Ineffectiveness of exogenous RNase on the antibody plaque response of immunized mice.免疫中的核酸酶。II. 外源性核糖核酸酶对免疫小鼠抗体空斑反应的无效性
Clin Exp Immunol. 1970 Apr;6(4):619-25.
8
[19S-hemolysin formation in the mouse following immunization with hemoglobin and serum lipoproteins].[用血红蛋白和血清脂蛋白免疫小鼠后19S溶血素的形成]
Naturwissenschaften. 1968 Oct;55(10):494. doi: 10.1007/BF00599720.
9
The immunosuppressive effect of RES "blockade" with ethyl stearate emulsion on cellular formation of antibody to sheep erythrocytes.硬脂酸乙酯乳剂对RES“阻断”对绵羊红细胞抗体细胞形成的免疫抑制作用。
Proc Soc Exp Biol Med. 1970 Feb;133(2):423-7. doi: 10.3181/00379727-133-34488.
10
Virus tumorigenesis and immunity: influence of immunostimulation and immunodepression.病毒致瘤作用与免疫：免疫刺激和免疫抑制的影响
Johns Hopkins Med J Suppl. 1974;3:187-209.

引用本文的文献

1
Immune response with particular reference to the use of multiple antigens.免疫反应，尤其涉及多种抗原的使用。
Calif Med. 1968 Dec;109(6):452-7.
2
Early antibody-forming cells of double specificity.具有双重特异性的早期抗体形成细胞。
Immunology. 1971 Jan;20(1):57-66.
3
The immune response to (3-amino, 5-succinylaminobenzoyl)-p-aminophenylarsenic acid. Immunofluorescent studies of cells making anti-arsanilic acid antibody or anti-m-aminosuccinanilic acid antibody.对（3-氨基，5-琥珀酰氨基苯甲酰基）-对氨基苯胂酸的免疫反应。产生抗对氨基苯胂酸抗体或抗间氨基琥珀酰苯胺酸抗体的细胞的免疫荧光研究。
Immunology. 1970 Jun;18(6):807-19.
4
Specificity of antibodies in single cells after immunization with antigens bearing several antigenic determinants. Study with a new paired staining technique.用带有多个抗原决定簇的抗原免疫后单细胞中抗体的特异性。采用一种新的配对染色技术进行研究。
Immunology. 1970 Apr;18(4):483-91.