Chakrabarty A K, Friedman H
Clin Exp Immunol. 1970 Apr;6(4):619-25.
The effect of bovine ribonuclease on the immune response of mice to sheep erythrocytes was studied. Mice were injected either with a polyribonuclease (poly-RNase) complex once before immunization, or with multiple daily injections of soluble RNase before and after immunization. The number of individual haemolysin-forming cells in the spleens of the animals was determined, as were the serum antibody titres to the erythrocytes. There was no evidence of an immunosuppressive effect in any of the treated animals, as compared to normal, non-treated controls, under conditions in which a marked immunosuppression had been noted in other studies.
研究了牛核糖核酸酶对小鼠针对绵羊红细胞免疫反应的影响。在免疫前，给小鼠注射一次多核糖核酸酶（poly-RNase）复合物，或者在免疫前后每天多次注射可溶性核糖核酸酶。测定了动物脾脏中单个溶血素形成细胞的数量以及针对红细胞的血清抗体滴度。与正常未处理的对照相比，在其他研究中已观察到明显免疫抑制的条件下，未发现任何处理过的动物有免疫抑制作用的证据。
