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1
Recurrent fever of unknown etiology: failure to demonstrate association between fever and plasma unconjugated etiocholanolone.不明病因的复发性发热：未能证实发热与血浆未结合表雄酮之间存在关联。
J Clin Invest. 1969 Mar;48(3):558-63. doi: 10.1172/JCI106014.
2
A case of periodic fever--reevaluation of etiocholanolone fever as an established clinical entity.
Horm Metab Res. 1988 Jun;20(6):364-6. doi: 10.1055/s-2007-1010837.
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[Familial Mediterranean fever with high serum unconjugated etiocholanolone level].
Acta Clin Belg. 1971;26(1):36-43.
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Urticaria in association with etiocholanolone fever.与本胆烷醇酮热相关的荨麻疹。
Br J Dermatol. 1981 Jul;105(1):109-12. doi: 10.1111/j.1365-2133.1981.tb00892.x.
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[Recurrent fever of unknown etiology lasting more than 6 months. Report on 85 patients].
Dtsch Med Wochenschr. 1982 Jul 2;107(26):1003-7. doi: 10.1055/s-2008-1070062.
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Measurement of testosterone and 17-ketosteroids in plasma by the double isotope dilution derivative technique.
J Clin Endocrinol Metab. 1968 Jul;28(7):949-77. doi: 10.1210/jcem-28-7-949.
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Determination of unconjugated etiocholanolone in human plasma using gas-liquid chromatography.
Clin Chim Acta. 1968 Apr;20(1):167-9. doi: 10.1016/0009-8981(68)90401-4.
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[Studies on etiocholanolone fever: Serum unconjugated eticholanolone concentration determined by radioimmunoassay].
Nihon Naika Gakkai Zasshi. 1977 Nov 10;66(11):1555-61.
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Radioimmunoassay for etiocholanolone.
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["Etiocholanolone fever"?].
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5β-Reduced steroids and human Δ(4)-3-ketosteroid 5β-reductase (AKR1D1).5β-还原甾体与人类Δ(4)-3-酮甾体5β-还原酶（AKR1D1）。
Steroids. 2014 May;83:17-26. doi: 10.1016/j.steroids.2014.01.013. Epub 2014 Feb 8.
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Granulomatous hepatitis and prolonged fever of unknown origin.肉芽肿性肝炎与不明原因的长期发热。
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Studies on steroid fever: I. Production of leukocyte pyrogen in vitro by etiocholanolone.甾体热研究：I. 依替可醇诱导白细胞致热原的体外产生。
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Double isotope derivative assay of aldosterone in biological extracts.生物提取物中醛固酮的双同位素衍生物测定法。
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ETIOCHOLANOLONE FEVER.本胆烷醇酮热
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PLASMA KETOSTEROIDS AND TESTOSTERONE IN MAN: A STUDY OF THE PITUITARY-TESTICULAR AXIS.人体中的血浆酮类固醇与睾酮：垂体 - 睾丸轴的研究
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EXPERIMENTAL ETIOCHOLANOLONE FEVER.实验性本胆烷醇酮热
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Increased urinary and plasma etiocholanolone and related steroids in a boy with virilizing adrenal hyperplasia and periodic fever.
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Studies on pyrogenic steroids. I. Separation, identification, and measurement of unconjugated dehydroepiandrosterone, etiocholanolone, and adrosterone in human plasma.致热类固醇的研究。I. 人血浆中游离脱氢表雄酮、本胆烷醇酮和雄酮的分离、鉴定及测定
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Metabolism of 4-C14-testosterone in human subjects. III. Fate of androsterone and etiocholanolone.4-C14-睾酮在人体中的代谢。III. 雄酮和表雄酮的去向。
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不明病因的复发性发热：未能证实发热与血浆未结合表雄酮之间存在关联。

Recurrent fever of unknown etiology: failure to demonstrate association between fever and plasma unconjugated etiocholanolone.

作者信息

George J M, Wolff S M, Diller E, Bartter F C

出版信息

J Clin Invest. 1969 Mar;48(3):558-63. doi: 10.1172/JCI106014.

DOI:10.1172/JCI106014
PMID:4886315
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC535721/
Abstract

A sensitive method for determination of plasma unconjugated etiocholanolone by double-isotope-derivative dilution has been described. The mean values for normal subjects was 0.038+/-0.003 (SEM) mug/100 ml.40 patients, 20 with familial Mediterranean fever and 20 with other diseases characterized by recurrent fever were studied. The over-all mean concentration of plasma unconjugated etiocholanolone for the patients (febrile or afebrile) was 0.101 +/-0.012 mug/100 ml, significantly above that of normals. Mean plasma values for the patients while they were febrile did not differ from the mean values when they were afebrile. It is suggested that the concentration of plasma unconjugated etiocholanolone is not related to fever in these patients.

摘要

已描述了一种通过双同位素衍生稀释法测定血浆中未结合表雄酮的灵敏方法。正常受试者的平均值为0.038±0.003（标准误）微克/100毫升。对40例患者进行了研究，其中20例患有家族性地中海热，20例患有以反复发热为特征的其他疾病。患者（发热或不发热）血浆中未结合表雄酮的总体平均浓度为0.101±0.012微克/100毫升，显著高于正常水平。患者发热时的血浆平均值与不发热时的平均值无差异。提示这些患者血浆中未结合表雄酮的浓度与发热无关。