Samokhvalov V P
Genetika. 1979 Sep;15(9):1681-7.
A special statistic method of confrontation of diseases with aggravation hereditary in the group "parents - children" is proposed. This method can be used under clinical formalization of the diseases. It is shown on a model group parents - children (118 pairs) suffering with schizophrenia, that statistical confrontation makes possible to work out group and individual prognoses in the descending generation. It is found that invariability in the descending generation is provided by a small number of stable indices, other symptoms being variable. Statistic description of the disease symptoms in the descending generation is of interest for planning genetic interpretation.
提出了一种针对“父母-子女”组中具有加重遗传性疾病的特殊统计方法。该方法可在疾病的临床形式化情况下使用。在患有精神分裂症的父母-子女模型组(118对)中表明,统计对比使得能够为后代制定群体和个体预后。研究发现,后代的不变性由少数稳定指标提供,其他症状则是可变的。后代疾病症状的统计描述对于规划遗传解释具有重要意义。