Rose A G, Timme A H, Price S K, Emms M, Dale J
Histopathology. 1979 Sep;3(5):421-22. doi: 10.1111/j.1365-2559.1979.tb03023.x.
The changes of myospherulosis were observed in masses from the buttocks of three patients. Ultrastructural examination of parent bodies and spherules from two patients revealed some spherules to contain dense bodies and filaments. Spherules had a double electron dense wall: the outer layer had a thickness corresponding to that of a cell membrane. Incubation of packed red blood cells with tetracycline ointment produced a similar electron dense deposit on the inner aspect of the cell membrane of the erythrocytes. No filaments or parent bodies were seen. Our findings support the hypothesis that myospherulosis represents altered red blood cells. The filaments seen in our patients may represent polymers of haemoglobin. It is suggested that parent bodies may be derived from histiocytes.
在三名患者臀部肿物中观察到了肌球形体病的变化。对两名患者的原体和球形体进行超微结构检查发现，一些球形体含有致密小体和细丝。球形体有双层电子致密壁：外层厚度与细胞膜相当。用四环素软膏孵育浓缩红细胞，在红细胞细胞膜内侧产生了类似的电子致密沉积物。未见到细丝或原体。我们的研究结果支持肌球形体病代表红细胞改变的假说。我们患者中所见的细丝可能代表血红蛋白聚合物。有人提出，原体可能来源于组织细胞。
