Chodera A, Konkiewicz B, Nowakowska E, Godlewski J
Int J Clin Pharmacol Biopharm. 1979 Jul;17(7):299-302.
The cardio-vascular reactions after i.m. application of 0.4 mg/kg of TA (imipramine, amitryptyline and nortryptyline) were compared in normotonics and patients suffering from essential hypertonia. It was found, that systolic blood pressure decreased significantly after the drugs only in hypertonic patients, whereas diastolic blood pressure fall was marked more in the normotonic group. In both groups, no apparent changes in heart action were noticed after the drugs. The TA caused a stronger increase of urine excretion of NE, E, VMA and NMN and MN in hypertonics than in normotonics.
比较了在正常血压者和原发性高血压患者中肌肉注射0.4mg/kg的三环类抗抑郁药（丙咪嗪、阿米替林和去甲替林）后的心血管反应。结果发现，这些药物仅使高血压患者的收缩压显著下降，而舒张压下降在正常血压组更为明显。两组患者用药后心脏活动均未出现明显变化。三环类抗抑郁药使高血压患者尿中去甲肾上腺素、肾上腺素、香草扁桃酸、去甲变肾上腺素和变肾上腺素的排泄量比正常血压者增加得更多。
