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交替治疗设计:一种在单一受试者中比较两种治疗效果的策略。

Alternating treatments design: one strategy for comparing the effects of two treatments in a single subject.

作者信息

Barlow D H, Hayes S C

出版信息

J Appl Behav Anal. 1979 Summer;12(2):199-210. doi: 10.1901/jaba.1979.12-199.

DOI:10.1901/jaba.1979.12-199
PMID:489478
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1311363/
Abstract

A little used and often confused design, capable of comparing two treatments within a single subject, has been termed, variously, a multielement baseline design, a multiple schedule design, and a randomization design. The background of these terms is reviewed, and a new, more descriptive term, Alternating Treatments Design, is proposed. Critical differences between this design and a Simultaneous Treatment Design are outlined, and experimental questions answerable by each design are noted. Potential problems with multiple treatment interference in this procedure are divided into sequential confounding, carryover effects, and alternation effects and the importance of these issues vis-a-vis other single-case experimental designs is considered. Methods of minimizing multiple treatment interference as well as methods of studying these effects are outlined. Finally, appropriate uses of Alternating Treatments Designs are described and discussed in the context of recent examples.

摘要

一种较少使用且常被混淆的设计,能够在单个受试者内比较两种治疗方法,它有多种不同的称呼,如多元素基线设计、多重日程安排设计和随机化设计。本文回顾了这些术语的背景,并提出了一个更具描述性的新术语——交替治疗设计。概述了该设计与同时治疗设计之间的关键差异,并指出了每种设计可回答的实验问题。此程序中多重治疗干扰的潜在问题分为顺序混淆、遗留效应和交替效应,并考虑了这些问题相对于其他单病例实验设计的重要性。概述了将多重治疗干扰降至最低的方法以及研究这些效应的方法。最后,结合近期实例描述并讨论了交替治疗设计的适当应用。

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