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为什么卵巢畸胎瘤是良性的,而睾丸畸胎瘤却是恶性的?

Why are ovarian teratomas benign whilst teratomas of the testis are malignant?

作者信息

Riley P A, Sutton P M

出版信息

Lancet. 1975 Jun 21;1(7921):1360-2. doi: 10.1016/s0140-6736(75)92265-5.

Abstract

A mechanism is suggested to account for the fact that most ovarian teratomas are benign (dermoid cysts) whereas testicular teratomas are almost always malignant. The mechanism advanced assumes that malignancy is cause by a recessive mutation, and then shows that the known facts of germ-cell development will produce the homozygous (malignant) state in the male but the heterozygous counterpart in the female. It is proposed that the benign nature of ovarian teratomas is a reflection of this heterozygous genotype.

摘要

有人提出一种机制来解释为何大多数卵巢畸胎瘤是良性的(皮样囊肿),而睾丸畸胎瘤几乎总是恶性的。所提出的机制假定恶性是由隐性突变引起的,然后表明生殖细胞发育的已知事实会在男性中产生纯合(恶性)状态,而在女性中产生杂合状态。有人提出卵巢畸胎瘤的良性本质反映了这种杂合基因型。

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