新型条件性耐大肠杆菌素突变体
New class of conditional colicin-tolerant mutants.
作者信息
Nagel de Zwaig R
出版信息
J Bacteriol. 1969 Jul;99(1):78-84. doi: 10.1128/jb.99.1.78-84.1969.
Abstract
A new class of temperature-dependent tol mutants of Escherichia coli expresses tolerance to colicins only after growth at higher temperatures. Colicin sensitivity or tolerance, acquired by growth at 30 or 41 C, respectively, is not lost upon incubation at the other temperature in the presence of chloramphenicol. The kinetics of conversion from sensitivity to tolerance and vice versa have been analyzed. In one instance, the tol VIII temperature-dependent phenotype was due to the modifying role of a str-r mutation on the suppression of a tol VIII amber mutant by the suppressor mutation suII. The bearing of the present findings on the role of the tol genes is discussed.
摘要
一类新型的大肠杆菌温度依赖性tol突变体仅在较高温度下生长后才表现出对大肠杆菌素的耐受性。分别在30℃或41℃下生长获得的对大肠杆菌素的敏感性或耐受性，在氯霉素存在的情况下于另一温度下孵育时不会丧失。已经分析了从敏感性转变为耐受性以及反之亦然的动力学。在一个实例中，tol VIII温度依赖性表型是由于str-r突变对抑制突变体suII对tol VIII琥珀突变体的抑制作用的修饰作用。讨论了本研究结果对tol基因作用的影响。
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