单次服用索他洛尔24小时后运动诱发的心动过速和肾素释放受到抑制。
Blunting of exercise-induced tachycardia and renin release 24 hours after a single dose of sotalol.
作者信息
Kiowski W, Bühler F R, Van Brummelen P, Küng M
出版信息
J Clin Pharmacol. 1979 Aug-Sep;19(8-9 Pt 2):513-5. doi: 10.1002/j.1552-4604.1979.tb02516.x.
Abstract
Sotalol significantly reduces resting and exercise-stimulated heart rate and plasma renin activity 2 hours and to a lesser degree also 24 hours after oral administration of a single 200-mg dose in healthy volunteers. Because of this 24-hour beta-adrenoceptor blocking effect, sotalol should be suitable for once-daily dosing in clinical practice.
摘要
在健康志愿者中，单次口服200毫克剂量的索他洛尔后2小时，其可显著降低静息和运动刺激后的心率以及血浆肾素活性，24小时时这种降低作用程度较小。由于这种24小时的β-肾上腺素能受体阻断作用，索他洛尔在临床实践中应适合每日一次给药。
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