Keithley E M, Feldman M L
J Comp Neurol. 1979 Dec 1;188(3):429-442. doi: 10.1002/cne.901880306.
Spiral ganglion cells in the cochleas of Sprague-Dawley rats in various age groups were counted in order to assess the extent and location of cell degeneration with age. Cells in every tenth section of serially sectioned plastic embedded cochleas were counted in the light microscope. The median cell number for the 1- to 2-month-old animals was 15,800 cells. This number was first seen to be significantly reduced (-14%) in the 23-month-old animals. At 27 to 29 months the ganglion cell number was reduced by 20%, while at 33 to 34 months there was a 17% loss. Losses were found throughout the length of the ganglion with the greatest losses at the lower basal and apical ends. In the oldest group, these losses amounted to 28% and 33%, respectively. Type II ganglion cells first showed a significant decrease in number in the 27- to 29-month-old group, when a 32% loss was seen. The same loss was seen in the 33- to 34-month-old group. Unlike the type I cells which are lost throughout the length of the ganglion, type II cells were not significantly reduced in number at the basal end, but decreased by as much as 42% in the middle and apical regions.
为了评估螺旋神经节细胞随年龄增长而发生的细胞变性程度和位置，对不同年龄组的Sprague-Dawley大鼠耳蜗中的螺旋神经节细胞进行了计数。在光学显微镜下，对连续切片的塑料包埋耳蜗的每第十个切片中的细胞进行计数。1至2月龄动物的细胞中位数为15,800个。这个数字在23月龄的动物中首次出现显著减少（-14%）。在27至29月龄时，神经节细胞数量减少了20%，而在33至34月龄时，减少了17%。在神经节的整个长度上都发现了细胞损失，在较低的基部和顶端损失最大。在最老的组中，这些损失分别达到28%和33%。II型神经节细胞在27至29月龄组中首次出现数量显著减少，减少了32%。在33至34月龄组中也出现了同样的减少。与在神经节全长上都有损失的I型细胞不同，II型细胞在基部数量没有显著减少，但在中部和顶端区域减少了多达42%。
