Smith M G, Eddleston A L, Dominguez J A, Evans D B, Bewick M, Williams R
Br Med J. 1969 Nov 1;4(5678):275-8. doi: 10.1136/bmj.4.5678.275.
The leucocyte migration test, an in-vitro measure of cellular immunity, has been used to follow the changes in cell-mediated hypersensitivity to kidney and histocompatibility antigens in three patients after renal transplantation.Inhibition of leucocyte migration, indicating strong sensitization to the antigens used, occurred in each patient, starting five to seven days after transplantation. Satisfactory renal function had not been established in any of the patients at this time. In one case inhibition of leucocyte migration persisted almost continuously until the 24th day and was associated with poor renal function proved histologically to be due to rejection. Treatment with increased dosage of prednisone was associated with a rapid reversion to normal of the migration index and improvement in renal function. Later, inhibition of migration occurred again, and shortly afterwards the graft ceased to function. In the other two cases the migration index became normal without alteration in immunosuppressive therapy and a satisfactory diuresis followed. It is suggested that this simple test should prove useful in the specific diagnosis of rejection and in control of immunosuppressive therapy.
白细胞游走试验是一种细胞免疫的体外检测方法，已被用于观察3例肾移植患者对肾脏及组织相容性抗原的细胞介导超敏反应的变化。白细胞游走受到抑制，表明对所用抗原有强烈致敏反应，这种情况在每位患者移植后5至7天开始出现。此时，任何一位患者均未建立起满意的肾功能。在1例患者中，白细胞游走抑制几乎持续存在直至第24天，且与经组织学证实因排斥反应导致的肾功能不佳相关。增加泼尼松剂量进行治疗后，游走指数迅速恢复正常，肾功能也有所改善。后来，游走抑制再次出现，不久后移植物停止发挥功能。在另外2例患者中，游走指数在免疫抑制治疗未改变的情况下恢复正常，随后出现了满意的利尿效果。有人提出，这项简单的试验在排斥反应的特异性诊断及免疫抑制治疗的控制方面应会被证明是有用的。
