对来自纽芬兰一个遗传隔离群体的936份血清中IgD浓度与免疫球蛋白同种异型之间的关联进行研究。

A search for association between IgD concentrations and immunoglobulin allotypes in 936 sera from a genetic isolate in Newfoundland.

作者信息

Salimonu L S, Bryant D G, de Lange G, Marshall W H, Newton R M, Van Loghem E

出版信息

J Immunogenet. 1979 Apr;6(2):141-4. doi: 10.1111/j.1744-313x.1979.tb00338.x.

DOI:10.1111/j.1744-313x.1979.tb00338.x

Abstract

Immunoglobulin allotype (Gm) data has been analysed agaonst immunoglobulin D (IgD) concentrations in a population study in Newfoundland. There was no significant difference between the distribution of IgD concentrations in people homozygous for the alleles G1m(f) and G3m(b) when compared with people homozygous for the alleles G1m(a) and G3m(g). These findings, involving 573 homozygous individuals as opposed to ninety-eight in an earlier study on a New York population, do not confirm the earlier findings. Thus a genetic influence on IgD concentration by Gm genes or genes closely linked to them is not universally demonstrable by typing for these four markers and by using the Mancini technique for mearusing IgD concentration.

摘要

在纽芬兰进行的一项人群研究中，对免疫球蛋白同种异型（Gm）数据与免疫球蛋白D（IgD）浓度进行了分析。与G1m（a）和G3m（g）等位基因纯合子的人群相比，G1m（f）和G3m（b）等位基因纯合子人群的IgD浓度分布没有显著差异。这些发现涉及573名纯合个体，而早期一项针对纽约人群的研究中只有98名，并未证实早期的研究结果。因此，通过对这四个标记进行分型并使用曼西尼技术测量IgD浓度，并未普遍证明Gm基因或与其紧密连锁的基因对IgD浓度有遗传影响。