系统性红斑狼疮中的免疫球蛋白同种异型——一项中欧多中心研究的结果。SLE研究组

Immunoglobulin allotypes in systemic lupus erythematosus--results of a central European multicenter study. SLE Study Group.

作者信息

Hartung K, Coldewey R, Röther E, Pirner K, Specker C, Peter H H, Kalden J R, Lakomek H J, Deicher H, de Lange G G

机构信息

Department of Medicine, University Hannover, FRG.

出版信息

Exp Clin Immunogenet. 1991;8(1):11-5.

PMID:1910857

Abstract

Immunoglobulin heavy chains (G1m, G2m, G3m, A2m) and kappa light chain (Km) allotype and phenotype frequencies were examined in 323 central European Caucasian patients with systemic lupus erythematosus (SLE). No significant differences were found between the different allotype or phenotype frequencies of the SLE patients and a control group of healthy individuals. Our results indicate that Gm, A2m and Km allotypes do not represent susceptibility factors for SLE in Caucasians.

摘要

在323例中欧白种人系统性红斑狼疮（SLE）患者中检测了免疫球蛋白重链（G1m、G2m、G3m、A2m）和κ轻链（Km）的同种异型和表型频率。SLE患者与健康个体对照组之间在不同的同种异型或表型频率上未发现显著差异。我们的结果表明，Gm、A2m和Km同种异型并非白种人SLE的易感性因素。