青霉素对大肠杆菌中脯氨酸合成的抑制作用。
Inhibitory effect of penicillin on proline synthesis in Escherichia coli.
作者信息
Baich A
出版信息
J Bacteriol. 1969 Nov;100(2):969-73. doi: 10.1128/jb.100.2.969-973.1969.
Abstract
The production of glutamic gamma-semialdehyde, an intermediate in the synthesis of proline, was inhibited in Escherichia coli by physiological concentrations of penicillin. Sucrose (0.6 m) and sodium chloride (0.1 m) prevented penicillin inhibition of glutamic gamma-semialdehyde synthesis. Cells which were in the stationary phase, or which had been permitted to metabolize without growth, were insensitive to the effects of penicillin on glutamic gamma-semialdehyde synthesis.
摘要
脯氨酸合成过程中的中间产物γ-谷氨酸半醛的生成，在大肠杆菌中会受到生理浓度青霉素的抑制。蔗糖（0.6 m）和氯化钠（0.1 m）可防止青霉素对γ-谷氨酸半醛合成的抑制作用。处于稳定期的细胞，或者已被允许在无生长情况下进行代谢的细胞，对青霉素对γ-谷氨酸半醛合成的影响不敏感。
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