青霉素在不支持持续生长的培养基中诱导大肠杆菌裂解。
Penicillin-induced lysis of Escherichia coli in medium that does not support sustained growth.
作者信息
Berg C M, Anderson S V
出版信息
Antimicrob Agents Chemother. 1976 Apr;9(4):713-5. doi: 10.1128/AAC.9.4.713.
Abstract
Exponentially growing cells of an Escherichia coli auxotroph that are washed and resuspended in buffer containing a carbon source undergo sufficient growth to render them susceptible to penicillin-induced lysis, even in the absence of the required metabolite. This lysis is probably responsible for the reduction in intracellular enzyme activity previously attributed to a direct effect of penicillin upon the enzyme.
摘要
将一株大肠杆菌营养缺陷型的指数生长期细胞洗涤后重悬于含有碳源的缓冲液中，即使在没有所需代谢物的情况下，这些细胞也会经历足够的生长，从而使其易于受到青霉素诱导的裂解。这种裂解可能是先前归因于青霉素对酶的直接作用而导致的细胞内酶活性降低的原因。
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J Bacteriol. 1969 Nov;100(2):969-73. doi: 10.1128/jb.100.2.969-973.1969.
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Antimicrob Agents Chemother. 1975 Jan;7(1):110-2. doi: 10.1128/AAC.7.1.110.
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